Sulfonylureas : side effects and precautions

Sulfonylureas : Precautions And Side Effects

(Last Updated On: January 30, 2018)

What Is Sulfonylureas

Sulfonylureas are a collection of medicines used in the control of type 2 diabetes. Sulfonylureas lower blood glucose levels by exciting insulin release from the Beta cells of the pancreas.

Their action relies upon the presence of functioning Beta cells, therefore, sulfonylureas do not work in individuals with type 1 diabetes.

It obstructing ATP sensitive potassium channels in the Beta cells for insulin release, decreasing potassium porosity. This causes depolarization of the cell and will increase calcium entry, boosting insulin secretion.

sulfonylureas mechanism of action
sulfonylureas mechanism of action

list of sulfonylurea drugs








Glucotrol XL


Glynase PresTab




Sulfonylureas Side Effects

All medicines have side effects. however many people do not feel the side effects, or they’re able to deal with them. ask your pharmacist about the side effects of each medicine you’re taking. side effects are also listed in the information that comes together with your medicine.

Here are some important things to think about:

sometimes the benefits of the medicine are more important than any minor side effects.

side effects could get away when you’re taking the medicine for a while.

If aspect effects still bother you and you wonder if you should keep taking the medicine, call your doctor. The doctor could also be able to lower your dose or replace your medicine. don’t quickly quit taking your medicine unless your doctor tells you to.

Side effects of sulfonylureas may include:

Signs of low blood sugar, such as sweating, dizziness, confusion, or nervousness


Weight gain

Skin reactions

Upset stomach

Dark-colored urine

How are sulfonylureas taken?

Sulfonylureas are tablets that are taken anywhere from once a day to twice a day.

Each form of sulfonylurea is available in several dosages or strengths.

In general, your doctor can begin you off on the lowest dose and step by step increase the dose, as needed, till your blood sugars come into target range.

Sulfonylurea Precautions

Sulfonylureas shouldn’t be used by people with type 1 diabetes.

People with liver or kidney problems might not be able to take sulfonylureas. talk to your doctor if this is a concern.

Some sulfonylureas could build your skin more sensitive to daylight. Avoid needless exposure to the sun, and wear sunscreen and protective clothing while outdoors.

Sulfonylureas generally cause changes in your blood sugar levels. you should know the symptoms of high and low blood sugar, and what to do if you experience them.

Some oral diabetes drugs could increase your risk of serious heart problems.

Not treating your diabetes will harm your heart and different organs. talk to your doctor about these risks.

Your doctor will probably want to check your blood sugar and urine sugar levels often while you take a sulfonylurea. Keep all appointments with your doctor’s office and laboratory.

Consider wearing a diabetic ID bracelet to be sure you get correct treatment in case of an emergency.

Let your healthcare provider know you’re taking a sulfonylurea before having any type of medical procedure, as well as a dental procedure.

Inform your doctor about all medicine, non-medicine, illegal, herbal, nutritional, or dietary drugs you take before taking sulfonylurea.

Sulfonylureas and Alcohol

Alcohol could worsen certain side effects of sulfonylureas.

Limit or avoid drinking alcohol while taking these medicines.

Sulfonylureas and pregnancy

Tell your doctor if you are pregnant or may become pregnant while taking a sulfonylurea.

It’s not known whether these drugs are safe to use throughout pregnancy.

Also, talk to your healthcare provider before taking sulfonylureas if you are breastfeeding.


Reference :


American diabetes association


Rating: 5.0/5. From 2 votes.
Please wait...

Leave a Reply

Your email address will not be published. Required fields are marked *